diff --git a/src/include/c.h b/src/include/c.h
index ae978830daf..47b97a9eb73 100644
--- a/src/include/c.h
+++ b/src/include/c.h
@@ -120,6 +120,13 @@
 #define pg_attribute_unused()
 #endif
 
+/* Macro for disabling GCC alignment sanitizer */
+#ifdef __GNUC__
+#define pg_attribute_no_sanitize_alignment() __attribute__((no_sanitize("alignment")))
+#else
+#define pg_attribute_no_sanitize_alignment()
+#endif
+
 /*
  * pg_nodiscard means the compiler should warn if the result of a function
  * call is ignored.  The name "nodiscard" is chosen in alignment with
diff --git a/src/port/pg_crc32c_sse42.c b/src/port/pg_crc32c_sse42.c
index 3b94a7388ab..10fc01e1f06 100644
--- a/src/port/pg_crc32c_sse42.c
+++ b/src/port/pg_crc32c_sse42.c
@@ -18,6 +18,7 @@
 
 #include "port/pg_crc32c.h"
 
+pg_attribute_no_sanitize_alignment()
 pg_crc32c
 pg_comp_crc32c_sse42(pg_crc32c crc, const void *data, size_t len)
 {