diff --git a/src/include/c.h b/src/include/c.h
index ae978830da..a86342093e 100644
--- a/src/include/c.h
+++ b/src/include/c.h
@@ -132,6 +132,18 @@
 #define pg_nodiscard
 #endif
 
+/*
+ * Place this macro before functions that should be allowed to make misaligned
+ * accesses.  Think twice before using it on non-x86-specific code!
+ * Testing can be done with "-fsanitize=alignment -fsanitize-trap=alignment"
+ * on clang, or "-fsanitize=alignment -fno-sanitize-recover=alignment" on gcc.
+ */
+#if __clang_major__ >= 7 || __GNUC__ >= 5
+#define pg_attribute_no_sanitize_alignment() __attribute__((no_sanitize("alignment")))
+#else
+#define pg_attribute_no_sanitize_alignment()
+#endif
+
 /*
  * Append PG_USED_FOR_ASSERTS_ONLY to definitions of variables that are only
  * used in assert-enabled builds, to avoid compiler warnings about unused
diff --git a/src/port/pg_crc32c_sse42.c b/src/port/pg_crc32c_sse42.c
index 3b94a7388a..10fc01e1f0 100644
--- a/src/port/pg_crc32c_sse42.c
+++ b/src/port/pg_crc32c_sse42.c
@@ -18,6 +18,7 @@
 
 #include "port/pg_crc32c.h"
 
+pg_attribute_no_sanitize_alignment()
 pg_crc32c
 pg_comp_crc32c_sse42(pg_crc32c crc, const void *data, size_t len)
 {